VimOsteo

$18.99

Keywords: Bone and Joint Support, Neuromuscular Support, Immune and Heart Health, Blood Sugar Support, Soft Tissue Support

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Description

Keywords: Bone and Joint Support, Neuromuscular Support, Immune and Heart Health, Blood Sugar Support, Soft Tissue Support

Vitamin D

The skin synthesizes vitamin D when exposed to sunlight (1). There is wide variation in the amount the skin produces and as we age, it often does not synthesize enough (1). Vitamin D enhances calcium and phosphorous absorption in the gut (2, 3). Lack of vitamin D results in soft, as well as fragile bones. Vitamin D aids in the normal functioning of the immune system to mitigate against infection by viruses and bacteria (4). Vitamin D also has anti-inflammatory effect and aids in the modulation of the immune system (2). Inadequate Vitamin D is also associated with muscle weakness (5-7) and may facilitate joint pains (8, 9). It is also important for nervous system function (10, 11). Vitamin D is an antioxidant and supports the structural integrity of the DNA (12) . Vitamin D deficiency is also associated with low mood (13).

Vitamin K is essential for blood clotting to prevent excessive bleeding. Vitamin K also activates Matrix Gla protein (MGP), a protein in the walls of blood vessels and cartilages which prevents calcium from being deposited and clogging the blood vessels, and calcifying the soft tissues of the joints (14). Calcium is supposed to be deposited in the bones and tooth and not arterial blood vessels and soft tissues. When arterial blood vessels are clogged blood flow is restricted which can result in heart and peripheral vascular conditions (15).
Studies found an association of vitamin K intake with improved insulin sensitivity (16, 17). Vitamin K improves bone strength and reduces heart disease risk (18, 19). Bone is an active metabolic tissue with frequent turnover and thus requires readily supply of the necessary nutrients. Vitamin D enhances the effects of vitamin K (20).

TET METABOLIC’s VimOsteo is designed to provide ample levels of Vitamins K and D for effective physiologic functioning.

References

1. In: Ross AC, Taylor CL, Yaktine AL, Del Valle HB, editors. Dietary Reference Intakes for Calcium and Vitamin D. The National Academies Collection: Reports funded by National Institutes of Health. Washington (DC)2011.
2. Jones G, Strugnell SA, DeLuca HF. Current understanding of the molecular actions of vitamin D. Physiol Rev. 1998;78(4):1193-231.

3. DeLuca HF. The vitamin D story: a collaborative effort of basic science and clinical medicine. FASEB J. 1988;2(3):224-36.

4. Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab. 2008;4(2):80-90.

5. Rejnmark L. Effects of vitamin d on muscle function and performance: a review of evidence from randomized controlled trials. Ther Adv Chronic Dis. 2011;2(1):25-37.

6. Inderjeeth CA, Glennon D, Petta A, Soderstrom J, Boyatzis I, Tapper J. Vitamin D and muscle strength in patients with previous fractures. N Z Med J. 2007;120(1262):U2730.

7. Foo LH, Zhang Q, Zhu K, Ma G, Hu X, Greenfield H, et al. Low vitamin D status has an adverse influence on bone mass, bone turnover, and muscle strength in Chinese adolescent girls. J Nutr. 2009;139(5):1002-7.

8. Garfinkel RJ, Dilisio MF, Agrawal DK. Vitamin D and Its Effects on Articular Cartilage and Osteoarthritis. Orthop J Sports Med. 2017;5(6):2325967117711376.

9. Li S, Niu G, Wu Y, Du G, Huang C, Yin X, et al. Vitamin D prevents articular cartilage erosion by regulating collagen II turnover through TGF-beta1 in ovariectomized rats. Osteoarthritis Cartilage. 2016;24(2):345-53.

10.Wrzosek M, Lukaszkiewicz J, Wrzosek M, Jakubczyk A, Matsumoto H, Piatkiewicz P, et al. Vitamin D and the central nervous system. Pharmacol Rep. 2013;65(2):271-8.

11.Annweiler C, Schott AM, Berrut G, Chauvire V, Le Gall D, Inzitari M, et al. Vitamin D and ageing: neurological issues. Neuropsychobiology. 2010;62(3):139-50.

12. Halicka HD, Zhao H, Li J, Traganos F, Studzinski GP, Darzynkiewicz Z. Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3. Aging (Albany NY). 2012;4(4):270-8.

13. Wilkins CH, Sheline YI, Roe CM, Birge SJ, Morris JC. Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. Am J Geriatr Psychiatry. 2006;14(12):1032-40.

14. Akbari S, Rasouli-Ghahroudi AA. Vitamin K and Bone Metabolism: A Review of the Latest Evidence in Preclinical Studies. Biomed Res Int. 2018;2018:4629383.

15. Sigvant B, Hasvold P, Kragsterman B, Falkenberg M, Johansson S, Thuresson M, et al. Cardiovascular outcomes in patients with peripheral arterial disease as an initial or subsequent manifestation of atherosclerotic disease: Results from a Swedish nationwide study. J Vasc Surg. 2017;66(2):507-14 e1.

16. Choi HJ, Yu J, Choi H, An JH, Kim SW, Park KS, et al. Vitamin K2 supplementation improves insulin sensitivity via osteocalcin metabolism: a placebo-controlled trial. Diabetes Care. 2011;34(9):e147.

17. Sakamoto N, Nishiike T, Iguchi H, Sakamoto K. Possible effects of one week vitamin K (menaquinone-4) tablets intake on glucose tolerance in healthy young male volunteers with different descarboxy prothrombin levels. Clin Nutr. 2000;19(4):259-63.

18. Erkkila AT, Booth SL, Hu FB, Jacques PF, Lichtenstein AH. Phylloquinone intake and risk of cardiovascular diseases in men. Nutr Metab Cardiovasc Dis. 2007;17(1):58-62.

19. Scientific Opinion on the substantiation of health claims related to vitamin K and maintenance of bone (ID 123, 127, 128, and 2879), blood coagulation (ID 124 and 126), and function of the heart and blood vessels (ID 124, 125 and 2880) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal. 2009;7(10):1228.

20. Braam LA, Hoeks AP, Brouns F, Hamulyak K, Gerichhausen MJ, Vermeer C. Beneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study. Thromb Haemost. 2004;91(2):373-80.

Product Information

 

Keywords: Bone and Joint Support, Neuromuscular Support, Immune and Heart Health, Blood Sugar Support, Soft Tissue Support

Supplement Fact

Product Literature

Vitamin D

The skin synthesizes vitamin D when exposed to sunlight (1). There is wide variation in the amount the skin produces and as we age, it often does not synthesize enough (1). Vitamin D enhances calcium and phosphorous absorption in the gut (2, 3). Lack of vitamin D results in soft, as well as fragile bones. Vitamin D aids in the normal functioning of the immune system to mitigate against infection by viruses and bacteria (4). Vitamin D also has anti-inflammatory effect and aids in the modulation of the immune system (2). Inadequate Vitamin D is also associated with muscle weakness (5-7) and may facilitate joint pains (8, 9). It is also important for nervous system function (10, 11). Vitamin D is an antioxidant and supports the structural integrity of the DNA (12) . Vitamin D deficiency is also associated with low mood (13).

Vitamin K is essential for blood clotting to prevent excessive bleeding. Vitamin K also activates Matrix Gla protein (MGP), a protein in the walls of blood vessels and cartilages which prevents calcium from being deposited and clogging the blood vessels, and calcifying the soft tissues of the joints (14). Calcium is supposed to be deposited in the bones and tooth and not arterial blood vessels and soft tissues. When arterial blood vessels are clogged blood flow is restricted which can result in heart and peripheral vascular conditions (15).
Studies found an association of vitamin K intake with improved insulin sensitivity (16, 17). Vitamin K improves bone strength and reduces heart disease risk (18, 19). Bone is an active metabolic tissue with frequent turnover and thus requires readily supply of the necessary nutrients. Vitamin D enhances the effects of vitamin K (20).

TET METABOLIC’s VimOsteo is designed to provide ample levels of Vitamins K and D for effective physiologic functioning.

References

1. In: Ross AC, Taylor CL, Yaktine AL, Del Valle HB, editors. Dietary Reference Intakes for Calcium and Vitamin D. The National Academies Collection: Reports funded by National Institutes of Health. Washington (DC)2011.
2. Jones G, Strugnell SA, DeLuca HF. Current understanding of the molecular actions of vitamin D. Physiol Rev. 1998;78(4):1193-231.

3. DeLuca HF. The vitamin D story: a collaborative effort of basic science and clinical medicine. FASEB J. 1988;2(3):224-36.

4. Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab. 2008;4(2):80-90.

5. Rejnmark L. Effects of vitamin d on muscle function and performance: a review of evidence from randomized controlled trials. Ther Adv Chronic Dis. 2011;2(1):25-37.

6. Inderjeeth CA, Glennon D, Petta A, Soderstrom J, Boyatzis I, Tapper J. Vitamin D and muscle strength in patients with previous fractures. N Z Med J. 2007;120(1262):U2730.

7. Foo LH, Zhang Q, Zhu K, Ma G, Hu X, Greenfield H, et al. Low vitamin D status has an adverse influence on bone mass, bone turnover, and muscle strength in Chinese adolescent girls. J Nutr. 2009;139(5):1002-7.

8. Garfinkel RJ, Dilisio MF, Agrawal DK. Vitamin D and Its Effects on Articular Cartilage and Osteoarthritis. Orthop J Sports Med. 2017;5(6):2325967117711376.

9. Li S, Niu G, Wu Y, Du G, Huang C, Yin X, et al. Vitamin D prevents articular cartilage erosion by regulating collagen II turnover through TGF-beta1 in ovariectomized rats. Osteoarthritis Cartilage. 2016;24(2):345-53.

10.Wrzosek M, Lukaszkiewicz J, Wrzosek M, Jakubczyk A, Matsumoto H, Piatkiewicz P, et al. Vitamin D and the central nervous system. Pharmacol Rep. 2013;65(2):271-8.

11.Annweiler C, Schott AM, Berrut G, Chauvire V, Le Gall D, Inzitari M, et al. Vitamin D and ageing: neurological issues. Neuropsychobiology. 2010;62(3):139-50.

12. Halicka HD, Zhao H, Li J, Traganos F, Studzinski GP, Darzynkiewicz Z. Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3. Aging (Albany NY). 2012;4(4):270-8.

13. Wilkins CH, Sheline YI, Roe CM, Birge SJ, Morris JC. Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. Am J Geriatr Psychiatry. 2006;14(12):1032-40.

14. Akbari S, Rasouli-Ghahroudi AA. Vitamin K and Bone Metabolism: A Review of the Latest Evidence in Preclinical Studies. Biomed Res Int. 2018;2018:4629383.

15. Sigvant B, Hasvold P, Kragsterman B, Falkenberg M, Johansson S, Thuresson M, et al. Cardiovascular outcomes in patients with peripheral arterial disease as an initial or subsequent manifestation of atherosclerotic disease: Results from a Swedish nationwide study. J Vasc Surg. 2017;66(2):507-14 e1.

16. Choi HJ, Yu J, Choi H, An JH, Kim SW, Park KS, et al. Vitamin K2 supplementation improves insulin sensitivity via osteocalcin metabolism: a placebo-controlled trial. Diabetes Care. 2011;34(9):e147.

17. Sakamoto N, Nishiike T, Iguchi H, Sakamoto K. Possible effects of one week vitamin K (menaquinone-4) tablets intake on glucose tolerance in healthy young male volunteers with different descarboxy prothrombin levels. Clin Nutr. 2000;19(4):259-63.

18. Erkkila AT, Booth SL, Hu FB, Jacques PF, Lichtenstein AH. Phylloquinone intake and risk of cardiovascular diseases in men. Nutr Metab Cardiovasc Dis. 2007;17(1):58-62.

19. Scientific Opinion on the substantiation of health claims related to vitamin K and maintenance of bone (ID 123, 127, 128, and 2879), blood coagulation (ID 124 and 126), and function of the heart and blood vessels (ID 124, 125 and 2880) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal. 2009;7(10):1228.

20. Braam LA, Hoeks AP, Brouns F, Hamulyak K, Gerichhausen MJ, Vermeer C. Beneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study. Thromb Haemost. 2004;91(2):373-80.

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