Turmeric Curcumin

$21.99

Keywords: Anti-inflammatory, Antioxidant

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Description

Keywords: Anti-inflammatory, Antioxidant

Curcumin is the primary biologically active constituent of turmeric (curry powder) from the roots of the plant Curcuma longa (Turmeric). Other known components of turmeric are demethoxycurcumin, bisdemethoxycurcumin, cyclocurcumin etc., together referred to as Curcuminoids (1). Whiles Curcuminoids have been shown to have some biological action, it’s mostly Curcumin which effect the biological activities of Turmeric.

Poor absorption of Curcumin in the intestines, rapid breakdown and elimination limit its bioavailability (2). Different methods to overcome these challenges, such as compounding to oils or sugars or formulation with antioxidants (tocopherol and ascorbyl palmitate) and Black pepper (Piperine) have been utilized (2, 3). Piperine (BioPerine) is shown to be efficient in promoting the bioavailabilty of curcumin (3).

In the centuries old Ayurvedic medicine, Turmeric Curcumin has been used for different conditions (2, 4). Curcumin’s diverse biological effects are due mostly to its anti-inflammatory properties (2). Importantly, Curcumin suppress a molecule in the cell called NF-κB. NF-κB can turn on inflammatory genes setting off the whole inflammation cascade (3). NF-κB whiles it can activate inflammation genes can also directly or indirectly turn on other genes that causes common chronic diseases. That is a reason dysregulated inflammation is implicated in several ailments, including metabolic diseases (5), cardiovascular diseases (6), pulmonary diseases (7) and some cancers (8).

Curcumin is also a well noted antioxidant (3). Curcumin is also shown to provide protection for the brain cells and may promote memory improvement (2, 9, 10).

Importantly, while compounds with such robust anti-inflammation potential could produce undesirable side effects at modest blood concentrations, curcumin does not (11, 12).

References

1. Sandur SK, Pandey MK, Sung B, Ahn KS, Murakami A, Sethi G, et al. Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis. 2007;28(8):1765-73.

2. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol. 2009;41(1):40-59.

3. Prasad S, Tyagi AK, Aggarwal BB. Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. Cancer Res Treat. 2014;46(1):2-18.

4. Hatcher H, Planalp R, Cho J, Torti FM, Torti SV. Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci. 2008;65(11):1631-52.

5. Odrowaz-Sypniewska G. Markers of pro-inflammatory and pro-thrombotic state in the diagnosis of metabolic syndrome. Adv Med Sci. 2007;52:246-50.

6. Ali M, Girgis S, Hassan A, Rudick S, Becker RC. Inflammation and coronary artery disease: from pathophysiology to Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS). Coron Artery Dis. 2018.

7. Sevenoaks MJ, Stockley RA. Chronic Obstructive Pulmonary Disease, inflammation and co-morbidity–a common inflammatory phenotype? Respir Res. 2006;7:70.

8. Aggarwal BB, Shishodia S, Sandur SK, Pandey MK, Sethi G. Inflammation and cancer: how hot is the link? Biochem Pharmacol. 2006;72(11):1605-21.

9. Sumanont Y, Murakami Y, Tohda M, Vajragupta O, Watanabe H, Matsumoto K. Prevention of kainic acid-induced changes in nitric oxide level and neuronal cell damage in the rat hippocampus by manganese complexes of curcumin and diacetylcurcumin. Life Sci. 2006;78(16):1884-91.

10. Small GW, Siddarth P, Li Z, Miller KJ, Ercoli L, Emerson ND, et al. Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial. Am J Geriatr Psychiatry. 2018;26(3):266-77.

11. Srimal RC, Dhawan BN. Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent. J Pharm Pharmacol. 1973;25(6):447-52.

12. Lao CD, Ruffin MTt, Normolle D, Heath DD, Murray SI, Bailey JM, et al. Dose escalation of a curcuminoid formulation. BMC Complement Altern Med. 2006;6:10.

Product Information

Keywords: Anti-inflammatory, Antioxidant

Supplement Fact

Product Literature

Curcumin is the primary biologically active constituent of turmeric (curry powder) from the roots of the plant Curcuma longa (Turmeric). Other known components of turmeric are demethoxycurcumin, bisdemethoxycurcumin, cyclocurcumin etc., together referred to as Curcuminoids (1). Whiles Curcuminoids have been shown to have some biological action, it’s mostly Curcumin which effect the biological activities of Turmeric.

Poor absorption of Curcumin in the intestines, rapid breakdown and elimination limit its bioavailability (2). Different methods to overcome these challenges, such as compounding to oils or sugars or formulation with antioxidants (tocopherol and ascorbyl palmitate) and Black pepper (Piperine) have been utilized (2, 3). Piperine (BioPerine) is shown to be efficient in promoting the bioavailabilty of curcumin (3).

In the centuries old Ayurvedic medicine, Turmeric Curcumin has been used for different conditions (2, 4). Curcumin’s diverse biological effects are due mostly to its anti-inflammatory properties (2). Importantly, Curcumin suppress a molecule in the cell called NF-κB. NF-κB can turn on inflammatory genes setting off the whole inflammation cascade (3). NF-κB whiles it can activate inflammation genes can also directly or indirectly turn on other genes that causes common chronic diseases. That is a reason dysregulated inflammation is implicated in several ailments, including metabolic diseases (5), cardiovascular diseases (6), pulmonary diseases (7) and some cancers (8).

Curcumin is also a well noted antioxidant (3). Curcumin is also shown to provide protection for the brain cells and may promote memory improvement (2, 9, 10).

Importantly, while compounds with such robust anti-inflammation potential could produce undesirable side effects at modest blood concentrations, curcumin does not (11, 12).

References

1. Sandur SK, Pandey MK, Sung B, Ahn KS, Murakami A, Sethi G, et al. Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis. 2007;28(8):1765-73.

2. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol. 2009;41(1):40-59.

3. Prasad S, Tyagi AK, Aggarwal BB. Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. Cancer Res Treat. 2014;46(1):2-18.

4. Hatcher H, Planalp R, Cho J, Torti FM, Torti SV. Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci. 2008;65(11):1631-52.

5. Odrowaz-Sypniewska G. Markers of pro-inflammatory and pro-thrombotic state in the diagnosis of metabolic syndrome. Adv Med Sci. 2007;52:246-50.

6. Ali M, Girgis S, Hassan A, Rudick S, Becker RC. Inflammation and coronary artery disease: from pathophysiology to Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS). Coron Artery Dis. 2018.

7. Sevenoaks MJ, Stockley RA. Chronic Obstructive Pulmonary Disease, inflammation and co-morbidity–a common inflammatory phenotype? Respir Res. 2006;7:70.

8. Aggarwal BB, Shishodia S, Sandur SK, Pandey MK, Sethi G. Inflammation and cancer: how hot is the link? Biochem Pharmacol. 2006;72(11):1605-21.

9. Sumanont Y, Murakami Y, Tohda M, Vajragupta O, Watanabe H, Matsumoto K. Prevention of kainic acid-induced changes in nitric oxide level and neuronal cell damage in the rat hippocampus by manganese complexes of curcumin and diacetylcurcumin. Life Sci. 2006;78(16):1884-91.

10. Small GW, Siddarth P, Li Z, Miller KJ, Ercoli L, Emerson ND, et al. Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial. Am J Geriatr Psychiatry. 2018;26(3):266-77.

11. Srimal RC, Dhawan BN. Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent. J Pharm Pharmacol. 1973;25(6):447-52.

12. Lao CD, Ruffin MTt, Normolle D, Heath DD, Murray SI, Bailey JM, et al. Dose escalation of a curcuminoid formulation. BMC Complement Altern Med. 2006;6:10.

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